How and where to order Naltrexone Hydrochloride (ReVia) 50 mg tablets or capsules online on the Students for Opioid Solutions website:

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Naltrexone (trade names include ReVia, Antaxone, Depade, Nalerona, Nalorex, Naltima, Naltrexon, Nemexin, Nodict, Trexan, Vivitrol) is an anti alcohol and opioid medication from drugs used in addictive disorders pharmacological group. This medicine is prescribed for the therapy of alcoholism, alcohol or opioid use disorder. It is also in research studies or off-label used for the treatment of dissociative symptoms (such as depersonalization and derealization), behavioral disorders, self-injurious behaviors, sexual addiction, and other medical conditions. It works by reducing cravings and feelings of euphoria associated with substance use disorder.


ReVia (Naltrexone Hydrochloride) tablets


Related medications:

  • Acamprosate (Campral)
  • Buprenorphine (Subutex)
  • Buprenorphine, Naloxone (Zubsolv)
  • Bupropion (Wellbutrin)
  • Calcium Carbimide (Temposil)
  • Diamorphine (Heroin)
  • Disulfiram (Antabuse)
  • Levacetylmethadol (OrLAAM)
  • Levomethadone (L-Polamidon)
  • Lofexidine (Lucemyra)
  • Melatonin (Meloset)
  • Methadone (Methadose)
  • Methylnaltrexone (Relistor)
  • Nalmefene (Selincro)
  • Naloxone (Narcan)
  • Oxycodone (OxyContin)
  • Piracetam (Nootropil)
  • Varenicline (Champix, Chantix)
  • Zolpidem (Ambien)


    Pharmacological and medical categories:

  • Alcohol dependence therapy
  • Anti alcohol drugs
  • Antidotes
  • Behavioral treatment for alcoholism
  • Detoxifying agents
  • Drug dependence therapy
  • Drugs used in substance dependence
  • Opiate partial agonists
  • Opioid antagonists
  • Opioid treatment medications
  • Supportive care therapy


    ATC codes:

  • N - Nervous system
  • N07 - Other nervous system drugs
  • N07B - Drugs used in addictive disorders
  • N07BB - Drugs used in alcohol dependence
  • N07BB04 - Naltrexone


    ICD-10 codes:

  • Mental, Behavioral and Neurodevelopmental disorders - F01-F99
  • Alcohol related disorders - F10
  • Opioid related disorders - F11
  • Other nonpsychotic mental disorders - F48
  • Depersonalization-derealization syndrome - F48.1
  • Sexual dysfunction not due to a substance or known physiological condition - F52
  • Other sexual dysfunction not due to a substance or known physiological condition - F52.8
  • Symptoms and signs involving emotional state - R45
  • Nonsuicidal self-harm - R45.88


    Indications and usage (official label):

    ReVia (Naltrexone Hydrochloride) is indicated for use within a comprehensive treatment programme for alcohol dependence. It is also indicated as adjunctive therapy in the maintenance of formerly opioid-dependent patients who have ceased the use of opioids such as diamorphine (heroin) and morphine.


    Dosage and administration:

    The recommended dose is 1 tablet per day unless a different dose has been prescribed by your doctor.

  • Naltrexone Hydrochloride film-coated tablets taken orally with small amount of liquid.
  • Before starting to take ReVia film-coated tablets, you must not have used any other opiates for at least 7-10 days. Your healthcare provider can use a test to establish whether you are clear of these drugs before you start the treatment. Generally speaking, treatment begins at a dose of 1/2 tablet per day (25 mg), later increased to 1 tablet per day (50 mg).
  • This medication must be used exclusively for the disorder for which your doctor has prescribed this medicine.
  • It is important to follow your physician's instructions closely with respect to the dosage.
  • It is important that you take ReVia (Naltrexone HCl) tablets for the period of time prescribed by your healthcare professional. The treatment can last for three months or longer, according to the judgment of your doctor.

    Naltrexone pills should be combined with other forms of treatment.


    Dosage forms and strengths:

    ReVia (Naltrexone Hydrochloride) beige, round, biconvex, film-coated, scored tablet. Debossed with REVIA on one side and with a stylized b/275 on the scored side.


    Overdosage:

    There is limited clinical experience with ReVia overdosage in humans. In one study, subjects who received 800 mg daily naltrexone pills for up to one week showed no evidence of toxicity.

    In the mouse, rat and guinea pig, the oral LD50s were 1,100 to 1,550 mg/kg; 1,450 mg/kg; and 1,490 mg/kg; respectively. High doses of ReVia (generally >= 1,000 mg/kg) produced salivation, depression/reduced activity, tremors, and convulsions. Mortalities in animals due to high-dose naltrexone tablets administration usually were due to clonic-tonic convulsions and/or respiratory failure.

    Treatment of overdosage

    In view of the lack of actual experience in the treatment of ReVia (Naltrexone) overdose, patients should be treated symptomatically in a closely supervised environment. Physicians should contact a poison control center for the most up-to-date information.


    Contraindications:

  • Patients receiving opioid analgesics.
  • Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone) or partial agonists (e.g., buprenorphine).
  • Patients in acute opioid withdrawal.
  • Any individual who has failed the naloxone challenge test or who has a positive urine screen for opioids.
  • Any individual with a history of sensitivity to ReVia (Naltrexone HCl) tablets or any other components of this product. It is not known if there is any cross-sensitivity with naloxone or the phenanthrene containing opioids.


    Warnings and precautions:

  • Vulnerability to opioid overdose
  • Precipitated opioid withdrawal
  • Hepatotoxicity
  • Depression and suicidality
  • Ultra rapid opioid withdrawal


    Adverse reactions, side effects:

    The most common adverse events of naltrexone pills were difficulty sleeping, anxiety or nervousness, abdominal cramps and pain, feeling sick and/or being sick, lack of energy or strength, joint and/or muscle pain, headaches, fast or irregular heartbeat, restlessness.

    To report suspected adverse reactions of ReVia (Naltrexone Hydrochloride) tablets, contact Bristol-Myers Squibb pharmaceutical company or your local FDA.


    Drug interactions:

  • Studies to evaluate possible interactions between ReVia and drugs other than opiates have not been performed. Consequently, caution is advised if the concomitant administration of naltrexone tablets and other drugs is required.
  • The safety and efficacy of concomitant use of ReVia (Naltrexone HCl) pills and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.
  • Lethargy and somnolence have been reported following doses of ReVia and thioridazine.
  • Patients taking this medication may not benefit from opioid containing medicines, such as cough and cold preparations, antidiarrheal preparations, and opioid analgesics. In an emergency situation when opioid analgesia must be administered to a patient receiving ReVia, the amount of opioid required may be greater than usual, and the resulting respiratory depression may be deeper and more prolonged.


    Use in specific populations:

    Pregnancy

    There are no adequate and well-controlled studies in pregnant women. ReVia should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

    Labor and delivery

    Whether or not naltrexone tablets affects the duration of labor and delivery is unknown.

    Nursing mothers

    In animal studies, naltrexone and 6-beta-naltrexol were excreted in the milk of lactating rats dosed orally with naltrexone. Whether or not Revia is excreted in human milk is unknown. Because many drugs are excreted in human milk, caution should be exercised when this medication is administered to a nursing woman.

    Pediatric use

    The safe use of ReVia (Naltrexone Hydrochloride) in pediatric patients younger than 18 years old has not been established.

    Renal impairment

    Naltrexone Hydrochloride (ReVia) and its primary metabolite are excreted primarily in the urine, and caution is recommended in administering the drug to patients with renal impairment.

    Hepatic impairment

    An increase in naltrexone AUC of approximately 5- and 10-fold in patients with compensated and decompensated liver cirrhosis, respectively, compared with subjects with normal liver function has been reported. These data also suggest that alterations in naltrexone bioavailability are related to liver disease severity.


    Pregnancy categories:

  • B3 - Australia
  • C - United States (Risk cannot be ruled out)


    Salts and other forms:

  • Naltrexone Base
  • Naltrexone Hydrochloride
  • Naltrexone Hydrochloride Dihydrate


    Synonyms, international and chemical names:

  • Naltrecson
  • Naltrekson
  • Naltrexon
  • Naltreksoni
  • Naltrexona
  • Naltrexonum


    Brands, generics, trade names:

  • Antaxone - Zambon
  • Depade - Mallinckrodt
  • Nalerona - Silesia Laboratorios
  • Nalorex - Bristol-Myers Squibb, Schering-Plough, United Drug, Vianex, Vitoria Laboratorios
  • Naltima - Intas Pharmaceuticals
  • Naltrexon - Sandoz
  • Naltrexone - Accord Healthcare, Mallinckrodt, Mylan
  • Nemexin - Bristol-Myers Squibb, Torrex Pharma
  • Nodict - Sun Pharmaceutical Industries
  • ReVia - Bristol-Myers Squibb
  • Trexan - Bristol-Myers Squibb
  • Vivitrol - Johnson & Johnson


    APIs used in medicine in combinations with naltrexone:

  • Bupropion
  • Morphine
  • Oxycodone
  • Triamcinolone


    Here is a list of popular medications containing naltrexone as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Naltima
  • Tablets; Oral; Naltrexone Hydrochloride 50 mg
  • Intas Pharmaceuticals
  • Nodict
  • Tablets, Film-Coated; Oral; Naltrexone Hydrochloride 50 mg
  • Sun Pharmaceutical Industries
  • ReVia
  • Tablets, Film-Coated; Oral; Naltrexone Hydrochloride 50 mg
  • Bristol-Myers Squibb
  • Apotex
  • Armstrong Laboratorios de Mexico
  • Barr Laboratories
  • Baxter
  • Boots
  • Cristalia Produtos Quimicos Farmaceuticos
  • Duramed Pharmaceuticals
  • Olic Thailand
  • Orphan Pharmaceutical
  • Sanofi-Aventis
  • Torrex Pharma
  • United Drug
  • Vivitrol
  • Injectable; Injection; Naltrexone Hydrochloride 380 mg
  • Johnson & Johnson
  • Alkermes



  • References:

  • Naltrexone main article on Wikipedia: https://en.wikipedia.org/wiki/Naltrexone
  • Naltrexone compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Naltrexone
  • Naltrexone Hydrochloride compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Naltrexone-hydrochloride
  • Naltrexone medicine on DrugBank: https://go.drugbank.com/drugs/DB00704
  • Naltrexone Hydrochloride on DrugBank: https://go.drugbank.com/salts/DBSALT000670
  • Naltrexone FAQ on MedlinePlus (revised 10/15/2017): https://medlineplus.gov/druginfo/meds/a685041.html
  • Naltrexone Injection FAQ on MedlinePlus (revised 11/01/2010): https://medlineplus.gov/druginfo/meds/a609007.html
  • Opioid Misuse and Addiction Treatment on MedlinePlus: https://medlineplus.gov/opioidmisuseandaddictiontreatment.html
  • Mallinckrodt Naltrexone Hydrochloride film-coated tablet drug label info on DailyMed (revised February 17, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Vivitrol (Naltrexone) kit drug label info on DailyMed (revised March 10, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Naltrexone containing drugs on Drugs-About.com: https://drugs-about.com/ing/naltrexone.html
  • Naltrexone for sale on Pharma Doctor (revised December 2021): https://pharma-doctor.com/naltrexone.html
  • ReVia (Naltrexone Hydrochloride) tablets USP 50 mg official prescribing information from the U.S. FDA (revised 10/2013): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • ReVia (Naltrexone Hydrochloride) tablets product information from GP2U TeleHealth (revised 10/2013): https://gp2u.com.au/static/pdf/R/REVIA-PI.pdf
  • Vivitrol (Naltrexone Hydrochloride) 380 mg/vial for extended-release injectable suspension, for intramuscular use prescribing information from Vivitrol official website powered by Alkermes (revised 03/2021): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Vivitrol (Naltrexone Hydrochloride) injections medication guide from Vivitrol official website (revised March 2021): https://www.vivitrol.com/content/pdfs/medication-guide.pdf
  • Trexan (Naltrexone Hydrochloride) tablets product information from WebMD: https://www.webmd.com/drugs/2/drug-57804/...
  • Naltrexone tablets 50 mg prescribing information from Mallinckrodt pharmaceutical company website (revised 07/2017): https://www.mallinckrodt.com/Download.ashx...
  • Accord Naltrexone Hydrochloride 50 mg film-coated tablets package information leaflet on Medicines.org.uk (revised 11/2019): https://www.medicines.org.uk/emc/files/pil.6073.pdf

    Revised: December 2021



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