How and where to order Naltrexone Hydrochloride (ReVia) 50 mg tablets or capsules online on the Students for Opioid Solutions website:
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|Forms:||ReVia (Naltrexone HCl) 50 mg tablets
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Naltrexone (trade names include ReVia, Antaxone, Depade, Nalerona, Nalorex, Naltima, Naltrexon, Nemexin, Nodict, Trexan, Vivitrol) is an anti alcohol and opioid medication from drugs used in addictive disorders pharmacological group. This medicine is prescribed for the therapy of alcoholism, alcohol or opioid use disorder. It is also in research studies or off-label used for the treatment of dissociative symptoms (such as depersonalization and derealization), behavioral disorders, self-injurious behaviors, sexual addiction, and other medical conditions. It works by reducing cravings and feelings of euphoria associated with substance use disorder.
Buprenorphine, Naloxone (Zubsolv)
Calcium Carbimide (Temposil)
Varenicline (Champix, Chantix)
Pharmacological and medical categories:
Alcohol dependence therapy
Anti alcohol drugs
Behavioral treatment for alcoholism
Drug dependence therapy
Drugs used in substance dependence
Opiate partial agonists
Opioid treatment medications
Supportive care therapy
N - Nervous system
N07 - Other nervous system drugs
N07B - Drugs used in addictive disorders
N07BB - Drugs used in alcohol dependence
N07BB04 - Naltrexone
Mental, Behavioral and Neurodevelopmental disorders - F01-F99
Alcohol related disorders - F10
Opioid related disorders - F11
Other nonpsychotic mental disorders - F48
Depersonalization-derealization syndrome - F48.1
Sexual dysfunction not due to a substance or known physiological condition - F52
Other sexual dysfunction not due to a substance or known physiological condition - F52.8
Symptoms and signs involving emotional state - R45
Nonsuicidal self-harm - R45.88
Indications and usage (official label):
ReVia (Naltrexone Hydrochloride) is indicated for use within a comprehensive treatment programme for alcohol dependence. It is also indicated as adjunctive therapy in the maintenance of formerly opioid-dependent patients who have ceased the use of opioids such as diamorphine (heroin) and morphine.
Dosage and administration:
The recommended dose is 1 tablet per day unless a different dose has been prescribed by your doctor.
Naltrexone Hydrochloride film-coated tablets taken orally with small amount of liquid.
Before starting to take ReVia film-coated tablets, you must not have used any other opiates for at least 7-10 days. Your healthcare provider can use a test to establish whether you are clear of these drugs before you start the treatment. Generally speaking, treatment begins at a dose of 1/2 tablet per day (25 mg), later increased to 1 tablet per day (50 mg).
This medication must be used exclusively for the disorder for which your doctor has prescribed this medicine.
It is important to follow your physician's instructions closely with respect to the dosage.
It is important that you take ReVia (Naltrexone HCl) tablets for the period of time prescribed by your healthcare professional. The treatment can last for three months or longer, according to the judgment of your doctor.
Naltrexone pills should be combined with other forms of treatment.
Dosage forms and strengths:
ReVia (Naltrexone Hydrochloride) beige, round, biconvex, film-coated, scored tablet. Debossed with REVIA on one side and with a stylized b/275 on the scored side.
There is limited clinical experience with ReVia overdosage in humans. In one study, subjects who received 800 mg daily naltrexone pills for up to one week showed no evidence of toxicity.
In the mouse, rat and guinea pig, the oral LD50s were 1,100 to 1,550 mg/kg; 1,450 mg/kg; and 1,490 mg/kg; respectively. High doses of ReVia (generally >= 1,000 mg/kg) produced salivation, depression/reduced activity, tremors, and convulsions. Mortalities in animals due to high-dose naltrexone tablets administration usually were due to clonic-tonic convulsions and/or respiratory failure.
Treatment of overdosage
In view of the lack of actual experience in the treatment of ReVia (Naltrexone) overdose, patients should be treated symptomatically in a closely supervised environment. Physicians should contact a poison control center for the most up-to-date information.
Patients receiving opioid analgesics.
Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone) or partial agonists (e.g., buprenorphine).
Patients in acute opioid withdrawal.
Any individual who has failed the naloxone challenge test or who has a positive urine screen for opioids.
Any individual with a history of sensitivity to ReVia (Naltrexone HCl) tablets or any other components of this product. It is not known if there is any cross-sensitivity with naloxone or the phenanthrene containing opioids.
Warnings and precautions:
Vulnerability to opioid overdose
Precipitated opioid withdrawal
Depression and suicidality
Ultra rapid opioid withdrawal
Adverse reactions, side effects:
The most common adverse events of naltrexone pills were difficulty sleeping, anxiety or nervousness, abdominal cramps and pain, feeling sick and/or being sick, lack of energy or strength, joint and/or muscle pain, headaches, fast or irregular heartbeat, restlessness.
To report suspected adverse reactions of ReVia (Naltrexone Hydrochloride) tablets, contact Bristol-Myers Squibb pharmaceutical company or your local FDA.
Studies to evaluate possible interactions between ReVia and drugs other than opiates have not been performed. Consequently, caution is advised if the concomitant administration of naltrexone tablets and other drugs is required.
The safety and efficacy of concomitant use of ReVia (Naltrexone HCl) pills and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.
Lethargy and somnolence have been reported following doses of ReVia and thioridazine.
Patients taking this medication may not benefit from opioid containing medicines, such as cough and cold preparations, antidiarrheal preparations, and opioid analgesics. In an emergency situation when opioid analgesia must be administered to a patient receiving ReVia, the amount of opioid required may be greater than usual, and the resulting respiratory depression may be deeper and more prolonged.
Use in specific populations:
There are no adequate and well-controlled studies in pregnant women. ReVia should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Labor and delivery
Whether or not naltrexone tablets affects the duration of labor and delivery is unknown.
In animal studies, naltrexone and 6-beta-naltrexol were excreted in the milk of lactating rats dosed orally with naltrexone. Whether or not Revia is excreted in human milk is unknown. Because many drugs are excreted in human milk, caution should be exercised when this medication is administered to a nursing woman.
The safe use of ReVia (Naltrexone Hydrochloride) in pediatric patients younger than 18 years old has not been established.
Naltrexone Hydrochloride (ReVia) and its primary metabolite are excreted primarily in the urine, and caution is recommended in administering the drug to patients with renal impairment.
An increase in naltrexone AUC of approximately 5- and 10-fold in patients with compensated and decompensated liver cirrhosis, respectively, compared with subjects with normal liver function has been reported. These data also suggest that alterations in naltrexone bioavailability are related to liver disease severity.
B3 - Australia
C - United States (Risk cannot be ruled out)
Salts and other forms:
Naltrexone Hydrochloride Dihydrate
Synonyms, international and chemical names:
Brands, generics, trade names:
Antaxone - Zambon
Depade - Mallinckrodt
Nalerona - Silesia Laboratorios
Nalorex - Bristol-Myers Squibb, Schering-Plough, United Drug, Vianex, Vitoria Laboratorios
Naltima - Intas Pharmaceuticals
Naltrexon - Sandoz
Naltrexone - Accord Healthcare, Mallinckrodt, Mylan
Nemexin - Bristol-Myers Squibb, Torrex Pharma
Nodict - Sun Pharmaceutical Industries
ReVia - Bristol-Myers Squibb
Trexan - Bristol-Myers Squibb
Vivitrol - Johnson & Johnson
APIs used in medicine in combinations with naltrexone:
Here is a list of popular medications containing naltrexone as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
|Trade name of the drug
||Pharmaceutical forms and doses
||Tablets; Oral; Naltrexone Hydrochloride 50 mg
||Tablets, Film-Coated; Oral; Naltrexone Hydrochloride 50 mg
||Sun Pharmaceutical Industries
||Tablets, Film-Coated; Oral; Naltrexone Hydrochloride 50 mg
||Bristol-Myers SquibbApotexArmstrong Laboratorios de MexicoBarr LaboratoriesBaxterBootsCristalia Produtos Quimicos FarmaceuticosDuramed PharmaceuticalsOlic ThailandOrphan PharmaceuticalSanofi-AventisTorrex PharmaUnited Drug
||Injectable; Injection; Naltrexone Hydrochloride 380 mg
||Johnson & JohnsonAlkermes
Naltrexone main article on Wikipedia: https://en.wikipedia.org/wiki/Naltrexone
Naltrexone compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Naltrexone
Naltrexone Hydrochloride compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Naltrexone-hydrochloride
Naltrexone medicine on DrugBank: https://go.drugbank.com/drugs/DB00704
Naltrexone Hydrochloride on DrugBank: https://go.drugbank.com/salts/DBSALT000670
Naltrexone FAQ on MedlinePlus (revised 10/15/2017): https://medlineplus.gov/druginfo/meds/a685041.html
Naltrexone Injection FAQ on MedlinePlus (revised 11/01/2010): https://medlineplus.gov/druginfo/meds/a609007.html
Opioid Misuse and Addiction Treatment on MedlinePlus: https://medlineplus.gov/opioidmisuseandaddictiontreatment.html
Mallinckrodt Naltrexone Hydrochloride film-coated tablet drug label info on DailyMed (revised February 17, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Vivitrol (Naltrexone) kit drug label info on DailyMed (revised March 10, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Naltrexone containing drugs on Drugs-About.com: https://drugs-about.com/ing/naltrexone.html
Naltrexone for sale on Pharma Doctor (revised December 2021): https://pharma-doctor.com/naltrexone.html
ReVia (Naltrexone Hydrochloride) tablets USP 50 mg official prescribing information from the U.S. FDA (revised 10/2013): https://www.accessdata.fda.gov/drugsatfda_docs/label...
ReVia (Naltrexone Hydrochloride) tablets product information from GP2U TeleHealth (revised 10/2013): https://gp2u.com.au/static/pdf/R/REVIA-PI.pdf
Vivitrol (Naltrexone Hydrochloride) 380 mg/vial for extended-release injectable suspension, for intramuscular use prescribing information from Vivitrol official website powered by Alkermes (revised 03/2021): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Vivitrol (Naltrexone Hydrochloride) injections medication guide from Vivitrol official website (revised March 2021): https://www.vivitrol.com/content/pdfs/medication-guide.pdf
Trexan (Naltrexone Hydrochloride) tablets product information from WebMD: https://www.webmd.com/drugs/2/drug-57804/...
Naltrexone tablets 50 mg prescribing information from Mallinckrodt pharmaceutical company website (revised 07/2017): https://www.mallinckrodt.com/Download.ashx...
Accord Naltrexone Hydrochloride 50 mg film-coated tablets package information leaflet on Medicines.org.uk (revised 11/2019): https://www.medicines.org.uk/emc/files/pil.6073.pdf
Revised: December 2021
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